Theoretical model for the electrospinning nanoporous materials process

AbstractThis paper deals with modeling the electrospinning nanoporous materials process. The presented theoretical models offer an in-depth insight into the physical understanding of many complex phenomena and might be very useful at shedding light on the contributing factors. Many basic properties and some special properties (such as the numbers and sizes of the pores) are tunable by adjusting electrospinning parameters such as voltage, flow rate, and others. With the increase of voltage and the decrease of flow rate, ever-increasing numbers and ever-decreasing sizes of the nanoporous microspheres have appeared. Electrospun nanoporous materials which can be regarded as thousands of Helmholtz Resonators forming together will become a kind of excellent sound absorption material

Fractional variational iteration method via modified Riemann–Liouville derivative

AbstractThe aim of this paper is to present an efficient and reliable treatment of the variational iteration method (VIM) for partial differential equations with fractional time derivative. The fractional derivative is described in the Jumarie sense. The obtained results are in good agreement with the existing ones in open literature and it is shown that the technique introduced here is robust, efficient and easy to implement

Successful tricuspid valvectomy in a septic patient with tricuspid valve endocarditis

Abstract Endocarditis is characterized by vegetations, which is a mass of platelets, fibrin, micro-colonies of micro-organisms, and inflammatory cells, in the endocardium. Over the past three decades, the incidence of right-sided endocarditis has risen dramatically in Pakistan. We report a 36-year woman with a history of repeated intravenous analgesic injections for low back pain, presenting with high grade fever, sepsis and a white cell count of 44,000 with 90% neutrophils. Echocardiography showed large mobile vegetations on TricuspidValve (TV). Tricuspid Valve Endocarditis (TVE) is generally responsive to medical treatment; however, about 25% of TVE patients require surgical intervention. Long-term survival of a patient is possible without a prosthetic TV replacement, particularly if the pulmonary artery pressure is normal

An effective modification of the homotopy perturbation method for MHD viscous flow over a stretching sheet

AbstractIn this paper, we propose a powerful modification of the homotopy perturbation method that will accelerate the rapid convergence of series solution. The modified method is employed to solve the MHD boundary-layer equations. The viscous fluid is electrically conducting in the presence of a uniform applied magnetic field and the induced magnetic field is neglected for small magnetic Reynolds number. Similarity solutions of ordinary differential equation resulting from the momentum equation are obtained. Finally, some numerical comparisons among the new modified homotopy perturbation method, the standard homotopy perturbation, the Exact Solution and the Shooting method have been made, which manifest that the modified method is a very accurate and effective algorithm to solve the two-dimensional MHD viscous flow over a stretching sheet

An in silico approach to analyze HCV genotype-specific binding-site variation and its effect on drug-protein interaction

Genotype variation in viruses can affect the response of antiviral treatment. Several studies have established approaches to determine genotype-specific variations; however, analyses to determine the effect of these variations on drug-protein interactions remain unraveled. We present an in-silico approach to explore genotype-specific variations and their effect on drug-protein interaction. We have used HCV NS3 helicase and fluoroquinolones as a model for drug-protein interaction and have investigated the effect of amino acid variations in HCV NS3 of genotype 1a, 1b, 2b and 3a on NS3-fluoroquinolone interaction. We retrieved 687, 667, 101 and 248 nucleotide sequences of HCV NS3 genotypes 1a, 1b, 2b, and 3a, respectively, and translated these into amino acid sequences and used for genotype variation analysis, and also to construct 3D protein models for 2b and 3a genotypes. For 1a and 1b, crystal structures were used. Drug-protein interactions were determined using molecular docking analyses. Our results revealed that individual genotype-specific HCV NS3 showed substantial sequence heterogeneity that resulted in variations in docking interactions. We believe that our approach can be extrapolated to include other viruses to study the clinical significance of genotype-specific variations in drug-protein interactions

The Impact of Colorectal Conditions on Psychosocial Well Being of Caregivers and Patients Presenting to A Tertiary Care Hospital

Colorectal conditions such as Hirschsprung disease, anorectal malformation, fecal incontinence and spinal condition cause a significant stress among patients and their caregivers. Managing such disorders requires not only a one-time definitive surgery but a significant number of follow up visits, dietary modifications and long-term medication. The aim of this study was to estimate the psychosocial wellbeing of caregivers and patients suffering from these conditions

Features of the power-law fluid over cylinders in a channel via gap aspects: Galerkin finite element method (GFEM)-based study

The goal of this investigation is to carry out a comprehensive analysis of hydrodynamic forces, with particular attention being paid to the power-law fluid flow across cylinders and presence gap considerations. With the assistance of the Galerkin finite element method (GFEM), the discretization of the two-dimensional system of non-linear partial differential equations was successfully completed. The research is carried out with a significant variance of the flow behavior index n from .3 to 1.7, gap aspects Gp from 0 .0 to .3, and fixed Reynolds number Re 20. To obtain an extremely accurate solution, first, a coarse hybrid computational mesh needs to be developed, and then, more refinement must take place. The selection of the best possible case can be determined by comparing flow patterns, coefficients of drag and lift, and cylinder gaps. The shear-thickening behavior of fluids has a substantially greater influence on the drag characteristics than either the Newtonian or the shear-thinning behavior of fluids do. In addition to this, the shear-thickening action causes the upstream obstacle’s drag coefficient to increase because the gap spacing becomes more widespread

Prevalence of HCV in β-thalassemia major patients visiting tertiary care hospitals in Lahore – Pakistan

Post-transfusion hepatitis (PTH) is majorly caused by hepatitis C virus (HCV). So, recipients of blood/blood products, post-transfusion hepatitis (PTH), renal dialysis patients and intravenous drug users all represent high-risk groups for infection. The aim of the present research was to determine the prevalence of HCV antibody in β-thalassemia major patients visiting different tertiary care hospital in Lahore, Pakistan. HCV seroprevalence and risk factors were studied in 200 β-thalassemia major patients (24 females, 176 males) with different age groups by second generation ELISA during January 2013 to May 2013. Confirmed β-thalassemia major patients from three different tertiary care hospitals were selected with special reference to age, age at the time of diagnosis, frequency of transfusion and present clinical status. Among 200 patients, 82 (41%) were found reactive for HCV antibody with age range of 2 to 18 years with mean age of 8.5 years. This study showed that hemodialysis patients and β-thalassemia sufferers were at higher risk of having HCV infection; the prevalence being 41%

E-Healthcare Using Block Chain Technology and Cryptographic Techniques: A Review

The potential of information technology has influenced the efficiency and quality of healthcare worldwide. Currently, several republics are incorporating electronic health records (EHRs). Due to reluctance of technological adaptation & implementational complexities, electronic health record systems are not in practice. Due to the emphasis on achieving general compatibility, users may perceive systems as being imposed and providing insufficient customizability, which may exacerbate issues in a setting of national implementation. EHS improves patient safety and confidentiality and ensures operative, effective, well-timed, reasonable, and patient-centred care, all of which substantially impact healthcare quality. Blockchain technology has been used by the EHS system, which supports web-based accessibility and availability. The difficulties of exchanging medical data can now be overcome by consumers using an infrastructure based on cloud computing. A variety of cryptographic approaches have been employed to encrypt and safeguard the data. This review paper aims to highlight the role and impact of blockchain in EHR. The proposed research describes cryptography methods, their classifications, and the challenges associated with EHR to identify gaps and countermeasures

On the study of viscous fluid due to exponentially shrinking sheet in the presence of thermal radiation

In this paper, the effect of radiation on heat transfer in boundary layer flow over an exponentially shrinking sheet is investigated analytically. The similarity transformations are used to transform the partial differential equations to ordinary ones, and an analytical solution is obtained using the homotopy perturbation method. The heat transfer characteristics for different values of the Prandtl number, Eckert number, and radiation number are analyzed and discussed. Finally, the validity of results are verified by comparing with the existing numerical results. Results are presented in tabulated forms to study the efficiency and accuracy of the homotopy perturbation method